Biotechnology Focus

Laboratory Focus January 2012

Biotechnology Focus is Canada's leading authority on Canada's life science news. From biopharma and healthcare to ag-bio and clean tech, our readership includes life science professionals, C-level executives and researchers.

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2 NEWS MOUNT SINAI RESEARCHERS UNCOVER NEW MEANS FOR DEVELOPING CANCER THERAPIES The Samuel Lunenfeld Re- search Institute's Drs. Frank Sicheri, Tony Pawson and Sebastian Guettler, in col- laboration with Dr. Robert Rottapel at the Ontario Can- cer Institute, have uncov- ered the detailed architecture of a crucial component of Tankyrase, a protein linked to the bone development disor- der cherubism and involved in a myriad of cellular processes. The discovery is the first structural insight into pre- cisely how the enzyme cor- rectly identifies its targets, or substrates. The work provides researchers with a greater understanding of Tankyrase's cellular control processes, and may also lead to the de- velopment of new designer drugs to treat cancer. "Until now, we did not un- derstand, from a structural perspective, how Tankyrase Continued from page 3 PUBLISHER/EDITOR-IN-CHIEF Terri Pavelic STAFF WRITER Shawn Lawrence CONTRIBUTING WRITERS Guerman Pasmanik Kimberley Phipps William Faulkner NATIONAL ACCOUNT MANAGER Marcello Sukhdeo GRAPHIC DESIGNER Elena Pankova CONTROLLER John R. Jones Lab Water Replacement Cartridges For use in Millipore, Barnstead & most major brands of laboratory water purification systems. Many "bowl style" cartridges are available for Millipore and Barnstead water systems, including great prices on Super-Q system cartridges. We also have extremely low prices on cartridges for Millipore Compact and Century Range water systems. For ordering information or technical support, contact Wyvern Customer Service 1-877-998-3767 (USA and Canada) , or visit our website: Millipore & Super-Q are trademarks of Millipore Corporation & Barnstead of Thermo Fisher Scientific and are used only for identification purposes. MARKETING MANAGER Mary Malofy CIRCULATION DIRECTOR James Watson OFFICE: 24-4 Vata Court Aurora, ON L4G 4B6 Phone: 905-727-3875 Fax: 905-727-4428 E-mail: laboratory_focus@ SUBSCRIPTION INQUIRIES Fax: 905-727-4428 Laboratory Focus is published 6 times per year by Promotive Communications Inc. Legal Depository: National Library of Canada ISSN 40052410 Subscription rate in Canada $35/year; USA $60/year; other countries $100/year. All rights reserved. No part of this publication may be reproduced without written consent. Publications Mail Registration Number: 40052410 Return undeliverable Canadian addresses to circulation dept: 24-4 Vata Court Aurora, ON L4G 4B6 E-mail: If you would like to order hard copy or electronic reprints of articles, contact Sandra Service 905-727-3875 x228 ABC Membership Applied For January 2012 Laboratory Focus

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